How Long Does It take for L-Methylfolate to Work?
L-methylfolate is commonly
prescribed for suboptimal folate levels in depressed patients. It is also
prescribed for treating Hyperhomocysteinemia in schizophrenia patients. The
drug directly works as a methyl donor as well as a monoamine synthesis
modulator. The methylfolate supplement,
often termed as L-Methylfolate or L-5 MTHF supplement, is directly derived from
the folate that caters towards cell growth/reproduction, breakdown/utilization
of proteins, the formation of nucleic acids, and other functions. The beauty of
this supplement is that it helps in regulating a critical enzyme known as
tetrahydrobiopterin (BH4). As it acts as a Methyl donor for DNA methylation, it
can be termed as an epigenetic regulator. However, the reaction time of this
supplement is not immediate.
People often ask for how long to wait until it starts to work. Now, let's take a case of a depression
patient for instance. The onset of therapeutic actions of L-Methylfolate would
not be immediate. The delay may be around 2 weeks and in some cases even 4
weeks. In case the drug does not seem to be working within 6-8 weeks of intake;
the doctors may consider increasing the dosage. It varies greatly from patient
to patient, and there is no way to predict if, or when, it will work for a
particular individual. Most patients do
eventually have a positive reaction to the L-5 MTHF supplement, and there
is a number of success records. There are also a few medical instances where
the L-Methylfolate has therapeutic actions on the patient, but again the
chances are very low. However, once your body starts to respond, L-Methylfolate
will continue to work for many years thereby preventing the relapse of symptoms.
If the drug starts to work, the complete remission of current symptoms
becomes predictable. Also, the treatment makes sure for the prevention of
future relapses. However, one thing is worth remembering - the treatment
reduces or even eliminates the symptoms for sure but they are likely to reoccur
the moment medicine intake is stopped. Therefore, it is advisable to continue
the treatment until all the symptoms are gone. In case of treating depression,
the patient is advised to be under a treatment for one year after all the symptoms
are gone.
As already mentioned, there are few instances where any form of methylfolate, whether you say it L-5 MTHF
supplement or (6S)-5-Methylfolate, fails to improve certain conditions of
depression like insomnia, fatigue, and problems concentrating. At that time,
switching to another agent or adding an appropriate augmenting agent becomes
the alternative approach. Patients even get referred for psychotherapy. These
non-responders are termed as treatment-resistant or treatment-refractory.
With an approach towards providing some best augmenting combos, the
patient may need to go through certain tests - testing the Baseline folate
levels or Baseline homocysteine levels. The doctor may also consider genotyping
for deficient folate synthesis via MTHFR T alleles or MTHFD1 A alleles.
L-methylfolate does not have any side effects. It can cause a minimal
weight gain or sedation at max. In case of these minor side effects, the dose
can be lowered or may be divided into smaller doses.
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